Reponse to recent press
Vitrifixation today is a powerful research tool, but needs more research and development before anyone considers applying it in a context other than research. Additional tests for various kinds of efficacy beyond ultrastructure preservation (including preservation of proteomic and genomic information) should be completed and will provide critical information on vitrifixation’s capabilities. Vitrifixation, also known as ASC, has been demonstrated to preserve the connectomes of animals, a promising first step towards demonstrating efficacy of connectome preservation in humans. Vitrifixation’s efficacy at preserving biomolecules will be studied in the future. Once the areas of effectiveness of vitrifixation are known, the techniques, like all new surgical techniques, need be reviewed by both the medical and scientific community. Feedback from neuroscientists and thoughtful discussion from medical ethicists must be incorporated. We believe that clinical human brain preservation has immense potential to benefit humanity, but only if it is developed in the light, with input from medical and neuroscience experts. We believe that rushing to apply vitrification today would be extremely irresponsible and hurt eventual adoption of a validated protocol.